When trendsetting Oregon-based hotel brand Ace announced they were going to expand internationally, few would have picked Panama City's Casco Viejo neighborhood as one of the first ventures. After the American Trade Hotel opened in late 2013, though, everyone could see why. Mixing the grandeur and exceptional framework of the Art Nouveau neoclassical American Trade Building with the hip, modern sensibilities of Atelier Ace, this instantly became the most charming hotel in the city. Abandoned since the 1990s, the structure is now stunning, thanks to the help of local design team Conservatorio. There are high ceilings, hand-painted clay tiles, rocking chairs, and potted plants. Guest rooms vary in size from big to bigger, all decked out in a sort of Havanesque tropical-chic vibe, with wood floors and furniture that would do Hemingway proud. There's also a jazz bar, a farm-to-table restaurant, a rooftop pool, and a lobby café that roasts single-source Panamanian coffee.