If the Medici should miraculously return to Florence, surely the clan would move in here. Installed in the overhauled historic Palazzo della Gherardesca and a former convent, this spa hotel offers spectacular frescoes, museum-worthy sculptures, and Florentine artisanal works, with its oldest wing dating from the 1440s. Its grounds are on one of the largest private gardens in the city. Damask draperies, regal appointments in all the bedrooms, fabric-trimmed walls, ceramic floors, an elegant spa, rich marble bathrooms, luxurious beds and furnishings, and pools equipped with phones are just some of the features that make this perhaps the finest Four Seasons in Europe.